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Meloni AR, DeYoung MB, Lowe C, Parkes DG

Others use continuous daily dosing

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Human subjects Pancreata and islets from non-diabetic adult donors were obtained via a partnership with CORE (Center for Organ Recovery and Education)

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found no CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed (Dixon et al., 2014